Antiviral Res: Scientists find key molecules that inhibit Ebola virus infection
March 30, 2018 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];According to recent research by researchers from Georgia State University, a class of organic compounds is effective against Ebola and other viral infections.
Researchers have discovered that this compound, called benzoquinoline, inhibits the ability of Ebola to replicate and proliferate in cell culture. The results are published in the latest issue of Antiviral Research.
Ebola virus is a member of the linear virus, a membrane-enveloped single-stranded RNA virus that infects humans and causes severe symptoms. A large number of Ebola virus infections broke out in West Africa from 2013 to 2016. This is the largest linear virus infection in history. In this epidemic, 28,000 people were infected with the virus and 11,000 died.
There are currently no effective therapies or drugs for Ebola virus infection, so we urgently need new treatments. The current potential antiviral target is to kill the virus by blocking the synthesis of its RNA.
In this study, the authors screened 200,000 small molecule compounds and found that 56 compounds were able to exert significant inhibitory effects (70%), while the corresponding cytotoxicity was less than 20%, and eventually found three Compound structure of antiviral effect in vitro.
Later, the authors performed various types of virus treatment on human epithelial cells and HEK cells, and tested the antiviral effects of the above drugs, in which benzoquinoline has a broad spectrum of antiviral ability. Based on this result, the authors hope to develop drugs based on benzoquinoline against Ebola virus infection.
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