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| product Name: | Atorvastatin Calcium |
| CAS Registry Number: | 134523-03-8Â |
| Molecular Formula: | C66H68Ca2F2N4O10 |
| Molecular Weight:Â | 1195.4197264 |
| Appearance | white powder |
| Grade: | Pharmaceutical Grade |
| Packing: | 1KG/Package or as per your requirements |
| Application: | Lipid-lowering drugs |
Indications and Usage:
Atorvastatin is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Atorvastatin can lower the serum low-density lipoprotein cholesterol of some homozygous familial hypercholesterolemia patients, which is a population that rarely responds to other lipid-lowering drugs. It is clinically used to treat primary hypercholesterolemia, mixed hyperlipidemia, and hypertriglyceridemia, homozygous familial hypercholesterolemia, and it is used to prevent and treat atherosclerosis. Atorvastatin can also regulate blood lipids and combat atherosclerosis.
Mechanisms of Action:
Atorvastatin mainly inhibits HMGCoA reductase synthesis to inhibit cholesterol synthesis, reducing the amount of serum low-density lipoprotein cholesterol and triglycerides. Atorvastatin inhibits cells from synthesizing cholesterol, thus interrupting lipoprotein production, which causes serum total cholesterol levels to decrease, effectively lowers serum triglyceride levels, and increases serum high-density lipoprotein cholesterol levels.
Pharmacokinetics:
Rapidly absorbed after oral intake, reaches maximum blood concentration in 1-2 hours, and is not affected when taken with food. Its absolute bioavailability is about 12%, and its usage in inhibiting HMG-CoA reductase is about 30%. This low percentage is due to cleansing by gastrointestinal mucosa and the first round of metabolism in the liver. Its serum protein binding rate is above 98%. It is mainly metabolized in the liver by cytochrome P450 3A4, its metabolites are O-hydroxylate, its derivatives and various beta oxidants, and these o-hydroxylates are active against o-hydroxylate metabolites. This drug and its metabolites are metabolized in and/or out of the liver and excreted mainly in bile, and small amounts (less than 2% of dosage amount) is excreted through urine. This drug's average serum clearing half-life is 14 hours, and its active metabolites' half-life is 20-30 hours.
Uses:
A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
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Product Packaging
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery
Usually within 3-7 working days after payment.
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;Â
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Service
we will try our best to satisfied you.
1. Tailor-made for every customers.Â
2. Third-party test for the products you demand.Â
3. Test your counter-samples and produce them for you.Â
4. Best discount for old customers.Â
5. Reasonable &Â competitive price, fast lead time.
6. Sample is available for your evaluation &Â Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply &Â service.
11. Strictly on selecting raw materials.
After-Sale Service
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Â
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before sellingÂ
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Process and Advice:
Â
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
Our Advantages
1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .
3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .
4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. Fast delivery:we have stock, so we can delivery quickly once payment is received.
6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.
7. Competitive prices:A discount would be given when you make a large order.
Please feel free to contact me if you need any further information~
Â
Â
Â
| product Name: | Atorvastatin Calcium |
| CAS Registry Number: | 134523-03-8Â |
| Molecular Formula: | C66H68Ca2F2N4O10 |
| Molecular Weight:Â | 1195.4197264 |
| Appearance | white powder |
| Grade: | Pharmaceutical Grade |
| Packing: | 1KG/Package or as per your requirements |
| Application: | Lipid-lowering drugs |
Indications and Usage:
Atorvastatin is a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Atorvastatin can lower the serum low-density lipoprotein cholesterol of some homozygous familial hypercholesterolemia patients, which is a population that rarely responds to other lipid-lowering drugs. It is clinically used to treat primary hypercholesterolemia, mixed hyperlipidemia, and hypertriglyceridemia, homozygous familial hypercholesterolemia, and it is used to prevent and treat atherosclerosis. Atorvastatin can also regulate blood lipids and combat atherosclerosis.
Mechanisms of Action:
Atorvastatin mainly inhibits HMGCoA reductase synthesis to inhibit cholesterol synthesis, reducing the amount of serum low-density lipoprotein cholesterol and triglycerides. Atorvastatin inhibits cells from synthesizing cholesterol, thus interrupting lipoprotein production, which causes serum total cholesterol levels to decrease, effectively lowers serum triglyceride levels, and increases serum high-density lipoprotein cholesterol levels.
Pharmacokinetics:
Rapidly absorbed after oral intake, reaches maximum blood concentration in 1-2 hours, and is not affected when taken with food. Its absolute bioavailability is about 12%, and its usage in inhibiting HMG-CoA reductase is about 30%. This low percentage is due to cleansing by gastrointestinal mucosa and the first round of metabolism in the liver. Its serum protein binding rate is above 98%. It is mainly metabolized in the liver by cytochrome P450 3A4, its metabolites are O-hydroxylate, its derivatives and various beta oxidants, and these o-hydroxylates are active against o-hydroxylate metabolites. This drug and its metabolites are metabolized in and/or out of the liver and excreted mainly in bile, and small amounts (less than 2% of dosage amount) is excreted through urine. This drug's average serum clearing half-life is 14 hours, and its active metabolites' half-life is 20-30 hours.
Uses:
A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
Â
Product Packaging
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag),or as required.
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery
Usually within 3-7 working days after payment.
Shipping
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;Â
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Service
we will try our best to satisfied you.
1. Tailor-made for every customers.Â
2. Third-party test for the products you demand.Â
3. Test your counter-samples and produce them for you.Â
4. Best discount for old customers.Â
5. Reasonable &Â competitive price, fast lead time.
6. Sample is available for your evaluation &Â Formulation development.
7. Faster delivery:Sample order in stock and 3-7 days for bulk production.
8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder
9. All inquiries will be replied within 12 hours.
10. Dedication to quality, supply &Â service.
11. Strictly on selecting raw materials.
After-Sale Service
1) International Authorized Third-Party Test For The Products You Demand.
2) 30 Days Warranty of quality of goods.
Â
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of products and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before sellingÂ
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Process and Advice:
Â
| Make an order | Please make clear what product and what quantity you need |
| Quote | Prices and Specifications details would be offered for you to consider and confirm |
| Payment ways | Bank Transfer, Western Union, Money Gram and Bitcoin |
| Delivery ways | All Express Modes(EMS, DHL, TNT, FedEx, UPS, etc.) |
| Shipping address | Provide your Valid and Correct destination address info(if possible with post code, phone number). |
| Packing | Select best ways according to quantity and safety degree(Super discreet, professional and experienced) |
| Lead time | Within 8 hours upon receipt of payment |
| Package picture | Photos of package would be offered to tell apart the items |
| Tracking number | Offered once it is released |
| Shipping time | 3-7 working days (Door-to-Door) |
| After-sale service | 24/7 Online for any problems |
Our Advantages
1. Rich experience:Our company is a professional production leading factory in China in pharmaceutical area of many years.Â
2. Discreet package :The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also taken into consideration .
3. Top quality. High quality guaranteed, once any problem is found, the package would be reshipped for you .
4. Security Shipping:Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. Fast delivery:we have stock, so we can delivery quickly once payment is received.
6. Quality service:we will give you warm after-sale service,if any question we will reply you within 24 hours.
7. Competitive prices:A discount would be given when you make a large order.
Please feel free to contact me if you need any further information~
Â
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Ruicheng Lvman BioPharmaceutical Co,Ltd , https://www.rclvman.com