At the China Biological Congress yesterday, Gao Fu, Chen Junshi and other 20 academicians of the two academies, together with more than 50 first-line bio-enterprises, such as Zhongcai Group, Tasly Group and WuXi PharmaTech, discussed the future prospects of biomedicine in China and explored Hubei and Wuhan Optics Valley biomedical industry development direction.
It is understood that this bio-conference has 14 high-level forums involving innovative biopharmaceuticals, vaccines, in vitro diagnostics, medical devices, medical quality, precision medicine , biological breeding, bio-environmental protection, cold chain management, bio-investment and financing, smart medical care and Health and other fields. “Basic is the area where the Optics Valley bio-industry is focusing or about to enter,†said Li Bing, director of the Optics Valley Bio-City Industry Division, especially for precision medicine and biological breeding, which will be the two major directions for the future development of Bio City.
He said that precision medicine will provide people with more accurate, efficient and safe prediction, diagnosis and personalized medicine. It is more tailored than the existing medical treatment methods. Cell therapy, smart medical, genetic science, etc. are all kinds of precision medicine. Before the cancer patient can use the drug, the gene can be tested first to see if the drug is suitable.
Cheng Jing, an academician of the Chinese Academy of Engineering and president of Boao Bio-Group Co., Ltd., also believes that the era of precision medicine has arrived. The company specializes in the development of biochips, and has developed and transformed a series of genetic testing products. After the promotion of hereditary deafness chips, 50,000 newborns can be directly prevented from causing drug abuse every year.
In addition, the seed that is regarded as the “life gate†of national food security will also be the core force of Optics Valley Bio City, and strive to create “Chinese speciesâ€. DuPont, Bayer and other Fortune 500 companies have already put some breeding research and development in Optics Valley. In the past six years, under the seat of six academicians including Zhang Inspired and Zhu Ying, this piece of land of only 3 square kilometers, last year's total income of nearly 30 billion yuan, has become the highest concentration of high-tech agricultural parks in the country.
Medicine Peptides and protein drugs are emerging. There are now 35 important therapeutics on the market, and the development of biotechnology and biopharmaceutical companies is becoming increasingly global. Biotechnology drug research focuses on the application of DNA recombinant technology to develop peptides, proteins, enzymes, hormones, vaccines, cell growth factors and monoclonal antibodies that can be used in clinical applications. According to Parexl's Pharmaceutical R&D Statistical Source Book, there are currently 723 biotech drugs under FDA review (including phase â…° to iii clinical and FDA evaluation), 700 drugs are in early stage (research and preclinical). More than 200 additional drugs are in the final stage of approval (Phase iii clinical and FDA evaluation). The basic dosage form of biotech drugs is lyophilized. Although the efficacy of conventional preparations has long been clinically proven, they need to be injected frequently for a long time due to their short half-life, which is difficult to accept from the perspective of psychological and economic burden on patients. To this end, scholars around the world mainly from two aspects to study and develop convenient and reasonable drug delivery approaches and new preparations: (1) embedment agent and sustained-release injection. â‘¡ Non-injectable dosage forms, such as respiratory inhalation, rectal administration, nasal administration, oral administration and transdermal administration, etc. Injectable preparations of sustained-release biotechnological drugs are new dosage forms with promising applications. Some of them, such as microsphere injections of luteinizing hormone releasing hormone (LHRH) analogues which can be sustained-release for 1 to 3 months, have been on the market. This paper focuses on this kind of preparations.Main types of peptides and protein drug sustained-release preparations The research and development of peptides and protein drug sustained-release preparations can be divided into two types, namely, embedment agent and microsphere injection, from the perspective of development process and dosage form. The shape of the implant is a hollow micro-fine rod, one end is closed, the other end is open, and the rod material is non-biodegradable polymer such as ptfe. The lumen was filled with a mixture of drugs and silica gel (silastic, polydimethylsiloxane). The implant is embedded under the skin, and the drug is released slowly through the opening of silica gel matrix. The American Physicians' Handbook (PDR) contains a product called Norplant? Levo-18 ethyl norethinnes, used in family planning. The preparation, each with a diameter of 2.4 mm and a length of 34 mm, is surgically implanted in the inner side of the patient's upper arm with 6 thin rods. The drug can be released in the body in zero-grade mode for up to 5 years, and then removed by surgery after release,1.1.2 Micro-osmotic pump embedding agent The United States Alza company in the 1970s developed an embedding agent shaped like a capsule, which is embedded in the skin or other parts. The body fluid can penetrate through the shell, dissolve the interlayer electrolytic layer, make the volume expansion of the interlayer pressure to the plastic inner cavity, and promote the drug solution from the opening of the fixed speed release. Many biomolecular drugs, such as insulin, heparin and nerve growth factor, have been reported as model drugs in vivo and in vitro. Implants have positive significance for the treatment of chronic patients who need long-term medication, but it has the following defects: â‘ must be surgically implanted. â‘¡ The skeleton material of the preparation is non-biodegradable polymer, which needs to be removed by surgery after release. â‘¢ The preparation has irritation and discomfort in local tissues. Evaluation methods for polypeptide protein drugs: 1. Liquid chromatography 2. Spectroscopic 3. Solvent-based versions are easy to use, but need to be kept at low temperatures (2-8 degrees Celsius).
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