Basic information:
Product Name: ProgesteroneÂ
Synonyms: PROGESTERONE-WATER SOLUBLE;progestin;PROGESTERONE;PRIMOLUT;17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;17alpha-Progesterone;3,20-Pregnene-4;4-Pregnen-3,20-dionÂ
CAS: 57-83-0Â
MF: C21H30O2Â
MW: 314.46Â
CAS:Â | 57-83-0Â |
MF:Â | C21H30O2Â |
MW: | 314.46Â |
EINECS:Â | 200-350-6Â |
Product Categories: MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates &Â Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;API;ENDOMETRIN;Plant extract;Pharma material;InhibitorsÂ
Mol File: 57-83-0.molÂ
Chemical Properties:
MP  128-132 °C(lit.)
alpha  186 º (c=1, ethanol)Â
refractive index  182 ° (C=2, Dioxane)Â
storage temp.  Store at RTÂ
solubility  H2O: 25 mg/mL, may be clear to slightly hazy
form  powder
Water Solubility  <0.1 g/100 mL at 19 ºCÂ
Merck  7773Â
Stability: Stable. Incompatible with strong oxidizing agents.Â
Safety Information:
Hazard Codes  Xn,T,FÂ
Risk Statements  40-45-62-36-20/21/22-11Â
Safety Statements  36/37-45-53-16Â
WGK Germany  3Â
RTECSÂ Â TW0175000
Usage And Synthesis:
Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.Â
Test method:
In the 40's, only chemical method can be used to monitor the excretion of pregnanediol which is the metabolism of progesterone in the urine of 24h, this could reflect the level of progesterone release.Â
Started from the 50's, progesterone levels in plasma could be determined not only by chemical methods, but also by biological methods and gas chromatography.
At the end of the 60's, radionuclides and protein competition were developed to determine progesterone.
In the 70's, the radiation immune assay and the radiation receptor method have appeared, which greatly improved the sensitivity and accuracy of the assay. When determination of progesterone in blood has been widely used, the determination of urinary progesterone has lost its importance. Normal value of follicular phase in urine was 1mg/24h, and in the corpus phase was 2-8mg/24h. Changes of progesterone levels in women of childbearing age can reflect the different stages of the menstrual cycle. For pregnant women, blood progesterone continued rising, which is not coincidence with the normal cycle. For the person of congenital 17α-hydroxylase deficiency syndrome, there is abnormal ratio of progesterone to 17α-Hydroxy progesterone, that is progesterone ascending while 17α-Hydroxy progesterone decreasing.
Preparation Products And Raw materials:
Raw materials Cyclohexanone-->16-Dehydropregnenolone acetate-->Aluminium isopropoxide-->PregnenoloneÂ
Preparation Products Deoxycorticosterone acetate -->-17-acetate-->17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate-->9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate-->9beta,11beta-epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate-->16,17-Epoxypregna-5,9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal)-->17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal-->16-DehydroprogesteroneÂ
 Estrogen Progesterone Raw Powder for Habitual Abortion Dysmenorrhea Amenorrhea CAS 57-83-0
Basic information:
Product Name: ProgesteroneÂ
Synonyms: PROGESTERONE-WATER SOLUBLE;progestin;PROGESTERONE;PRIMOLUT;17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;17alpha-Progesterone;3,20-Pregnene-4;4-Pregnen-3,20-dionÂ
CAS: 57-83-0Â
MF: C21H30O2Â
MW: 314.46Â
CAS:Â | 57-83-0Â |
MF:Â | C21H30O2Â |
MW: | 314.46Â |
EINECS:Â | 200-350-6Â |
Product Categories: MI;FINISHED MEDICINE;Steroids;ketone;Biochemistry;Steroids (Others);Intermediates &Â Fine Chemicals;Pharmaceuticals;Intracellular receptor;Steroid and Hormone;API;ENDOMETRIN;Plant extract;Pharma material;InhibitorsÂ
Mol File: 57-83-0.molÂ
Chemical Properties:
MP  128-132 °C(lit.)
alpha  186 º (c=1, ethanol)Â
refractive index  182 ° (C=2, Dioxane)Â
storage temp.  Store at RTÂ
solubility  H2O: 25 mg/mL, may be clear to slightly hazy
form  powder
Water Solubility  <0.1 g/100 mL at 19 ºCÂ
Merck  7773Â
Stability: Stable. Incompatible with strong oxidizing agents.Â
Safety Information:
Hazard Codes  Xn,T,FÂ
Risk Statements  40-45-62-36-20/21/22-11Â
Safety Statements  36/37-45-53-16Â
WGK Germany  3Â
RTECSÂ Â TW0175000
Usage And Synthesis:
Formerly biochemical study shows that progesterone modulates action as progestogens, clinical for the treatment of habitual abortion, dysmenorrhea, amenorrhea and other symptoms. One of progesterone's most important functions is as hormone drugs, to promote and maintain the uterine changes in the early stage of pregnancy, used in habitual abortion, irregular menstruation, etc.. In addition, progesterone also behaves as steroid hormone drug as well as progestogens, which is used in treatment of threatened abortion.Â
Test method:
In the 40's, only chemical method can be used to monitor the excretion of pregnanediol which is the metabolism of progesterone in the urine of 24h, this could reflect the level of progesterone release.Â
Started from the 50's, progesterone levels in plasma could be determined not only by chemical methods, but also by biological methods and gas chromatography.
At the end of the 60's, radionuclides and protein competition were developed to determine progesterone.
In the 70's, the radiation immune assay and the radiation receptor method have appeared, which greatly improved the sensitivity and accuracy of the assay. When determination of progesterone in blood has been widely used, the determination of urinary progesterone has lost its importance. Normal value of follicular phase in urine was 1mg/24h, and in the corpus phase was 2-8mg/24h. Changes of progesterone levels in women of childbearing age can reflect the different stages of the menstrual cycle. For pregnant women, blood progesterone continued rising, which is not coincidence with the normal cycle. For the person of congenital 17α-hydroxylase deficiency syndrome, there is abnormal ratio of progesterone to 17α-Hydroxy progesterone, that is progesterone ascending while 17α-Hydroxy progesterone decreasing.
Preparation Products And Raw materials:
Raw materials Cyclohexanone-->16-Dehydropregnenolone acetate-->Aluminium isopropoxide-->PregnenoloneÂ
Preparation Products Deoxycorticosterone acetate -->-17-acetate-->17,21-dihydroxy-16beta-methylpregna-1,4,9(11)-triene-3,20-dione 21-acetate-->9-Bromo-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione-21-acetate-->9beta,11beta-epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate-->16,17-Epoxypregna-5,9(11)-diene-3,20-dione cyclic bis(1,2-ethanediyl acetal)-->17-Hydroxy-16-methylpregna-5,9(11)-diene-3,20-dione 3,20-diethyleneketal-->16-DehydroprogesteroneÂ
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