Intelligent dissolved oxygen control in the fermentation process - introduction of infinite correlation technology

Dissolved oxygen is one of the most important parameters in aerobic fermentation control during microbial/cell fermentation. The size of dissolved oxygen has different effects on the formation and yield of fermentation products, and the results directly affect the efficiency of the whole fermentation.

Nowadays, the main method of controlling the dissolved oxygen in the fermenter on the market is to adjust the dissolved oxygen in the fermentation liquid by controlling the amount of the gas to be introduced or changing the proportion of oxygen in the gas. The higher level of control correlates the % dissolved oxygen in the fermentation broth with the amount of gas introduced, the rotational speed of the agitating paddle, the added feed and the tank pressure, and the % of dissolved oxygen is adjusted by the fermentation system automatically controlling these parameters. However, until today, no fermenter of any fermenter manufacturer can achieve a dissolved oxygen % associated with the above four parameters to achieve level 4 or higher. What is currently available on the market is the secondary correlation, and the relationship between % dissolved oxygen and agitation speed and aeration, and the best one is the Sartorius fermenter, which is automatically integrated due to its cabinet type. The associated control system enables automated multi-level (up to 4 levels) parameter correlation adjustments for the overall fermentation requirements.

In 2012, Hong Kong Global Analytical Testing Instrument Co., Ltd. introduced the Italian Solaris Fermentor/Bioreactor. Its intelligent control system and fully automated design realized the dissolved oxygen % associated with the above parameters above level 4, accurately stated in the parameters. Within the upper and lower limits, unrestricted correlation can be achieved, which makes the control of % dissolved oxygen more convenient and accurate during fermentation, and provides a higher concentration of dissolved oxygen in high-density culture.

The Solaris Fermentor/Bioreactor achieves a dissolved oxygen% unrestricted association interface as follows:

The above setting method is to set a % of dissolved oxygen that you need first, and then associate it with the stirring paddle speed. If the required dissolved oxygen % is achieved when the speed reaches the set upper limit, the next step is not performed. Level correlation; if you don't reach the % dissolved oxygen you need, then you can set the level 2 association. If the upper limit of the set parameter has not reached the % dissolved oxygen you need, then you can set the level 3 association. The upper limit of the set parameters has not reached the % dissolved oxygen you need, then you can set the level 4 association, and then cycle until you reach the % dissolved oxygen you need. In the process of setting the associated parameters, the same parameter can be set multiple times.

This feature of the Italian Solaris Fermentor/Bioreactor has surpassed similar manufacturers such as Sartorius (BÃ©ron) to varying degrees, making it a real technological innovation for users around the world.

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