Author: JIANG Zong to wait Date: 2019-01-18
When cardiovascular, cerebrovascular diseases such as hypertension, atherosclerosis, myocardial infarction, and stroke occur, a series of changes occur in the blood vessels. The complex process of balancing this cell with the internal environment is called revascularization. Remodeling). If you can improve the process of revascularization, it will help patients maintain vascular homeostasis and contribute to the treatment of the disease.
Mechanical factors have a direct and significant role in vascular remodeling. Taking the revascularization as the entry point and elucidating the mechanical effects of mechanical factors to induce the mechanobiology of vascular remodeling, it is of great significance for finding potential drug targets or new biomarkers for mechanical factors.
Recently, the team of the Institute of Mechanical Biology of the School of Life Science and Technology, Shanghai Jiao Tong University (Dr. Han Yue, Dr. Huang Kai, Dr. Yao Qingping and Professor Jiang Zonglai) published a review paper “Mechanobiology in vascular remodeling†in the National Science Review. Based on their recent achievements in vascular mechanical biology research, they introduced the mechanical stress response of vascular cells at home and abroad, the vascular mechanical signal transduction network based on high-throughput biotechnology, and non-coding RNA. Recent advances in mechanical regulation in vascular remodeling; summarizing some of the mechanisms of mechanical biology affecting the mechanical biology of revascularization (as shown).
Vascular cells, mainly endothelium and vascular smooth muscle cells, can sense various forms of mechanical force signals, such as shear stress and tensile strain, and convert them into intracellular biochemical signals, which are then mediated by intracellular cascades to ultimately regulate blood vessels. Morphology and function, affecting blood vessel reconstruction. In addition to chemical factors, interactions between vascular endothelial cells and smooth muscle cells, blood flow microsomes, platelets and suspension cells, vascular extracellular matrix, and adventitia are also involved in revascularization.
Mechanical biology is a new interdisciplinary field of biomechanics. Its mechanical signal sensing and response mechanism of graduate students clarify the relationship between the mechanical process and biological processes of the body, thereby developing new technologies with therapeutic or diagnostic significance and promoting the development of biomedicine. Choosing vascular remodeling as an entry point to explore some common and common pathogenesis of cardiovascular and cerebrovascular diseases, this research method will be more suitable for the complex characteristics of multi-gene and multi-pathogenic factors of cardiovascular and cerebrovascular diseases.
With the advancement of modern science and technology, the emergence of new interdisciplinary subjects has brought new opportunities for exploring major scientific issues in the field of life sciences and health. New ideas, new technologies and new breakthroughs generated by the multidisciplinary and integrated research institute are expected to be Ultimately, it will contribute to effective early warning, diagnosis and prevention of cardiovascular and cerebrovascular diseases.
Source: Science Network
Magnetic Bead Acid Nucleic Extraction Kit
In order to implement the requirements for the prevention and control of the new coronavirus pneumonia epidemic, all parts of the country are actively cooperating in the normalization of epidemic prevention and control. Each city has arranged multiple nucleic acid testing sampling points, and requires a negative nucleic acid test result within a few days. Public places are accessible, and the importance of nucleic acid testing for epidemic prevention and control is self-evident.
As of now, there are 13,000 medical and health institutions in the country that can carry out nucleic acid testing, and 153,000 professional and technical personnel are engaged in nucleic acid testing technology. The nucleic acid testing capacity has reached 57 million tubes per day. In order to help the prevention and control of the new crown epidemic, Yisheng Biology quickly launched the nucleic acid extraction reagent + 96-channel automatic nucleic acid extraction instrument. It only takes about 10 minutes to extract 96 nucleic acid samples at one time, and extract nucleic acid in a faster and more accurate way. Work becomes more efficient.
Magnetic Bead Swab Sample Viral DNA/RNA Extraction Kit can be used to isolate and purify high-quality viral DNA/RNA from various swabs and virus culture supernatants. By using magnetic beads with unique separation function and carefully optimized buffer system to efficiently capture the released nucleic acid, the extracted nucleic acid has high yield and good quality, which is suitable for various downstream application experiments, such as RT-qPCR, qPCR and other experiments.
Magnetic Bead Acid Nucleic Extraction Kit,Viral Dna Extraction Kit,Viral Rna Extraction Kit,Rapid Viral Rna Extraction Kit
Jilin Sinoscience Technology Co. LTD , https://www.contoryinstruments.com