Antineoplastic agents chlorambucil or chlorambucil: antineoplastic chemotherapy drugs, mutagenic or teratogenic effects, can cause fetal death or congenital malformations, particularly within 3 months of initial pregnancy. Busulfan: An antitumor drug that is mainly used for the treatment of chronic myeloid leukemia and polycythemia vera, bone marrow fibrosis, etc. It may increase the risk of fetal death and congenital malformation. Actinomycin: An anti-tumor antibiotic that can cause miscarriage or other fetal abnormalities. Purine: an anti-tumor drug for chorionic epithelial cancer, malignant mole, acute lymphoblastic leukemia and acute non-lymphocytic leukemia, chronic myeloid leukemia in the blast phase. May cause teratogenic or cause miscarriage. Methotrexate: anti-folate anti-tumor drugs with teratogenic effects. Seretide: An antitumor drug that is clinically used for breast cancer, ovarian cancer, and cervical cancer. Teratogenic potential. Fluorouracil: An anti-tumor chemotherapy drug that may cause teratogenicity. Mitomycin: An anti-tumor chemotherapy drug that may cause teratogenicity. Colchicine: An anti-tumor drug that has selective anti-inflammatory effects on acute gouty arthritis and may be teratogenic. Cyclophosphamide: An anti-tumor chemotherapy drug that has mutagenic or abnormal effects that can cause fetal death or congenital malformations. Vincristine: an anti-tumor chemotherapeutic agent, which has a prominent neurotoxicity, can promote the release of antidiuretic hormone (rarely seen in hyponatremia) and increase hepatotoxicity. Cisplatin: An anti-tumor chemotherapy drug that can cause bone marrow suppression, platelet and leukopenia. There are gastrointestinal reactions, nausea, vomiting, and nephrotoxicity.
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