Medicine is the root of a country. When the founding of New China bid farewell to the dilemma of using penicillin (a pennycin transliteration name, commonly used before liberation), China's pharmaceutical manufacturing industry developed rapidly. Although we have an advantage in terms of quantity, our quality is far from satisfactory. Good medicine requires good equipment to make. However, the status quo of the development of the pharmaceutical equipment industry in China is very worrying. Low-level, disorderly competition has almost become the industry standard.
China's pharmaceutical equipment production scale
At present, there are more than 1,000 professional pharmaceutical machinery factories in China with sales of 1 billion yuan. In previous years, due to the GMP certification of drug manufacturers, a large number of equipments needed to be replaced, which provided opportunities for the development of the pharmaceutical machinery industry. 2002 and 2003 were the “golden†periods for the growth of pharmaceutical machinery sales in China. By 2004, the number of enterprises had grown from 300 to more than 1,000. However, with the GMP certification of drug manufacturers coming to an end, more than 1,000 pharmaceutical machinery companies and more than 5,000 pharmaceutical production enterprises nationwide have formed a trend of 1000:5000, and supply exceeds demand, becoming the status of domestic demand. Pharmaceutical equipment companies have gone abroad to seek business opportunities.
Among the more than 1,000 pharmaceutical machinery companies, most of them are not strong except for a few key enterprises. The grades of their products are not high, and the depth of scientific research and development is not enough. As far as its scale is concerned, there are only a handful of pharmaceutical machinery companies with an annual output value of more than tens of millions of yuan.
The importance of pharmaceutical equipment in pharmaceutical production
The direct contact of pharmaceutical equipment with drugs, semi-finished products and raw materials is an important factor that causes errors in production and contamination of pharmaceuticals. It has been reported at home and abroad that, after washing the ampoules, vials, and infusion bottles with ultrasonic waves, the epidermis is loose and fragile and is easily soaked by the liquid for a long time. These phenomena are difficult to detect with the naked eye because the particles seen by the eye are at least 50 μm or more, while the microcapsules of the human body are only a few micrometers. Many undetected particles can block blood vessels and cause thrombosis; Many of the solid oral preparations such as smashing, granulating, mixing, tableting, coating, etc. are not 316 steels. These equipments have a rough welding and poor weld finish. After friction with the materials, wear debris will be mixed into the drug; As for the devices with transmission devices, the phenomenon of contamination of the machinery due to loose seals, mechanical wear and leakage of lubricating oil is not uncommon.
Three major bottlenecks in the development of China's pharmaceutical equipment industry
1, low level of replication, serious homogenization
Because the technical content of pharmaceutical equipment is not high, and the entry threshold for the industry is low, when GMP certification of pharmaceutical companies was carried out in China, the demand for equipment from pharmaceutical companies increased significantly, making small and medium-sized equipment companies make a concerted effort overnight. Since most enterprises start at a low level, mainly relying on imitation of foreign equipment, there is no high technical demand, resulting in a serious phenomenon of duplication of the same product, affecting the overall level of technology.
Taking drying equipment as an example, the vast majority of home-made drying equipment is supplied to the domestic market and is rarely exported to foreign countries. Even occasional export prices are not impressive. Although China has a large number of drying equipment factories, these plants are mainly concentrated in several regions. One of the important reasons why this situation is caused is that drying equipment is easy to copy, and dozens or even hundreds of companies produce the same model. Cause you can do what I can do, you can't do what I can't do. The brochures and promotional materials of each company are exactly the same, and the content is strikingly similar. Patented products are even more irrelevant, resulting in no special products for the manufacturers. Many drying equipment manufacturers produce the same model, the result is a price competition, the transaction is not backed by the technical content of equipment, but to win with low prices. It is well known that drying equipment is produced in one piece and in one piece. Each device has a certain amount of intellectual investment, and mental work is accompanied by the whole process of drying equipment manufacturing. However, in the economic negotiation with manufacturers, there is almost no technical content in the price of equipment, which means that the drying equipment is completely equivalent to general general equipment. However, the risk borne by dryer equipment manufacturers is much greater than other equipment. Without the economical accumulation of drying equipment manufacturers, there will be no technological development costs. It would be easy to imagine that no new aircraft will emerge in recent decades. On the other hand, previous unfavorable technology protection is also one of the important reasons for the low enthusiasm of developers. Drying equipment nameless brand products, developers have paid a lot of manpower, material resources and financial resources, but once the new model is introduced to the market, in a very short period of time there will be a number of imitation products, a new round of price competition to start again.
2, poor durability, lack of supporting equipment, poor appearance
Modern industrial production emphasizes continuous production and mass production so as to reduce production costs and maximize profits. However, due to industry competition and technological level constraints, many pharmaceutical equipment companies' products are often unsatisfactory in durability. Some pharmaceutical companies in the domestic multinational pharmaceutical giants do not consider home-made equipment when they purchase. The reason is that the durability of the equipment is poor. Although domestic equipment has a certain price advantage, but from the long-term use point of view, pharmaceutical companies use imported equipment, high efficiency, good quality, cost recovery is not slower than domestic goods.
In addition, there are a large number of stand-alone machines in domestic equipment, and there are few production lines. There are not many manufacturers of pharmaceutical equipment that can provide production lines. The configuration of the electromechanical components that are matched with the equipment is also a short board for domestic equipment. Such as drying equipment, a complete drying system consists of a variety of equipment, drying is a comprehensive technology involving a variety of disciplines, in addition to the technology itself, drying, can not do without other aspects of knowledge. For example, heating systems involve heat exchange or combustion technologies; electrical appliances involve automatic control technologies; dust removal and purification systems involve heterogeneous separation technologies; and sometimes they also involve environmental protection knowledge. The combination of many existing equipment and various equipment is unreasonable. The phenomenon of so-called big horse-drawn cars is extremely common, causing unnecessary waste. Mainly in the system design, can not consider the relationship between various parameters and supporting equipment according to the actual situation. For example, convection dryers are designed with different locations in which the equipment is installed, the air volume and the heat load of the heat exchange equipment are not the same, resulting in different types of fans, and there are numerous examples. In addition, the level of standardization and serialization of equipment is also relatively backward, and the interchangeability is poor, that is, the interchangeability of equipment produced by the same manufacturer is not satisfactory. Some foreign manufacturers compile numbers of all products of the factory. As long as the user asks which number of parts, they can provide exactly the same parts as the original. Users can easily maintain the equipment. The reliability of the parameters given in the specifications of many domestic manufacturers is not high, and the equipment specifications are too rough and incomplete, which increases the difficulty of user selection.
In terms of appearance, Chinese enterprises are even more difficult to pay attention to. On the other hand, the practice of enterprises in our country is to look at hard indicators, that is, equipment handling, work efficiency, and seldom look at the appearance. Second, domestically produced equipment often wins at low prices, making it difficult to add more value to the appearance, making it difficult to upgrade the appearance of the equipment.
3, the product has no characteristics, for the special needs of drugs, there is no corresponding solution
In the competition, homogeneity is the biggest drawback. In addition to some general equipment, special equipment is required for some special medicines. On the one hand, equipment companies need to actively consider the downstream pharmaceutical manufacturers. On the other hand, pharmaceutical manufacturers need to communicate with equipment companies. But this will inevitably increase the investment in technology research and development. In the small, scattered, and chaotic pharmaceutical equipment industry, only a few large companies can do it. Therefore, the industry reshuffle is inevitable.
For example, for drying equipment, there is a shortage of toxic drugs, high-temperature drugs, viscous drugs, flammable and explosive drugs, low-melting drugs, and other drugs that are drying in special requirements, which has become a constraint on domestic drying equipment to increase competitiveness and to go abroad. bottleneck.
With the further intensification of domestic competition in the pharmaceutical equipment industry, homogenization of products and backward technology have become increasingly clear. Foreign equipment is also plotting a vast market in China. Among internal and external troubles, only self-diagnosis and treatment can be carried out. After the pain, internal and external enhancements can be made to get out of the blue sky of pharmaceutical equipment in China.
China's pharmaceutical equipment production scale
At present, there are more than 1,000 professional pharmaceutical machinery factories in China with sales of 1 billion yuan. In previous years, due to the GMP certification of drug manufacturers, a large number of equipments needed to be replaced, which provided opportunities for the development of the pharmaceutical machinery industry. 2002 and 2003 were the “golden†periods for the growth of pharmaceutical machinery sales in China. By 2004, the number of enterprises had grown from 300 to more than 1,000. However, with the GMP certification of drug manufacturers coming to an end, more than 1,000 pharmaceutical machinery companies and more than 5,000 pharmaceutical production enterprises nationwide have formed a trend of 1000:5000, and supply exceeds demand, becoming the status of domestic demand. Pharmaceutical equipment companies have gone abroad to seek business opportunities.
Among the more than 1,000 pharmaceutical machinery companies, most of them are not strong except for a few key enterprises. The grades of their products are not high, and the depth of scientific research and development is not enough. As far as its scale is concerned, there are only a handful of pharmaceutical machinery companies with an annual output value of more than tens of millions of yuan.
The importance of pharmaceutical equipment in pharmaceutical production
The direct contact of pharmaceutical equipment with drugs, semi-finished products and raw materials is an important factor that causes errors in production and contamination of pharmaceuticals. It has been reported at home and abroad that, after washing the ampoules, vials, and infusion bottles with ultrasonic waves, the epidermis is loose and fragile and is easily soaked by the liquid for a long time. These phenomena are difficult to detect with the naked eye because the particles seen by the eye are at least 50 μm or more, while the microcapsules of the human body are only a few micrometers. Many undetected particles can block blood vessels and cause thrombosis; Many of the solid oral preparations such as smashing, granulating, mixing, tableting, coating, etc. are not 316 steels. These equipments have a rough welding and poor weld finish. After friction with the materials, wear debris will be mixed into the drug; As for the devices with transmission devices, the phenomenon of contamination of the machinery due to loose seals, mechanical wear and leakage of lubricating oil is not uncommon.
Three major bottlenecks in the development of China's pharmaceutical equipment industry
1, low level of replication, serious homogenization
Because the technical content of pharmaceutical equipment is not high, and the entry threshold for the industry is low, when GMP certification of pharmaceutical companies was carried out in China, the demand for equipment from pharmaceutical companies increased significantly, making small and medium-sized equipment companies make a concerted effort overnight. Since most enterprises start at a low level, mainly relying on imitation of foreign equipment, there is no high technical demand, resulting in a serious phenomenon of duplication of the same product, affecting the overall level of technology.
Taking drying equipment as an example, the vast majority of home-made drying equipment is supplied to the domestic market and is rarely exported to foreign countries. Even occasional export prices are not impressive. Although China has a large number of drying equipment factories, these plants are mainly concentrated in several regions. One of the important reasons why this situation is caused is that drying equipment is easy to copy, and dozens or even hundreds of companies produce the same model. Cause you can do what I can do, you can't do what I can't do. The brochures and promotional materials of each company are exactly the same, and the content is strikingly similar. Patented products are even more irrelevant, resulting in no special products for the manufacturers. Many drying equipment manufacturers produce the same model, the result is a price competition, the transaction is not backed by the technical content of equipment, but to win with low prices. It is well known that drying equipment is produced in one piece and in one piece. Each device has a certain amount of intellectual investment, and mental work is accompanied by the whole process of drying equipment manufacturing. However, in the economic negotiation with manufacturers, there is almost no technical content in the price of equipment, which means that the drying equipment is completely equivalent to general general equipment. However, the risk borne by dryer equipment manufacturers is much greater than other equipment. Without the economical accumulation of drying equipment manufacturers, there will be no technological development costs. It would be easy to imagine that no new aircraft will emerge in recent decades. On the other hand, previous unfavorable technology protection is also one of the important reasons for the low enthusiasm of developers. Drying equipment nameless brand products, developers have paid a lot of manpower, material resources and financial resources, but once the new model is introduced to the market, in a very short period of time there will be a number of imitation products, a new round of price competition to start again.
2, poor durability, lack of supporting equipment, poor appearance
Modern industrial production emphasizes continuous production and mass production so as to reduce production costs and maximize profits. However, due to industry competition and technological level constraints, many pharmaceutical equipment companies' products are often unsatisfactory in durability. Some pharmaceutical companies in the domestic multinational pharmaceutical giants do not consider home-made equipment when they purchase. The reason is that the durability of the equipment is poor. Although domestic equipment has a certain price advantage, but from the long-term use point of view, pharmaceutical companies use imported equipment, high efficiency, good quality, cost recovery is not slower than domestic goods.
In addition, there are a large number of stand-alone machines in domestic equipment, and there are few production lines. There are not many manufacturers of pharmaceutical equipment that can provide production lines. The configuration of the electromechanical components that are matched with the equipment is also a short board for domestic equipment. Such as drying equipment, a complete drying system consists of a variety of equipment, drying is a comprehensive technology involving a variety of disciplines, in addition to the technology itself, drying, can not do without other aspects of knowledge. For example, heating systems involve heat exchange or combustion technologies; electrical appliances involve automatic control technologies; dust removal and purification systems involve heterogeneous separation technologies; and sometimes they also involve environmental protection knowledge. The combination of many existing equipment and various equipment is unreasonable. The phenomenon of so-called big horse-drawn cars is extremely common, causing unnecessary waste. Mainly in the system design, can not consider the relationship between various parameters and supporting equipment according to the actual situation. For example, convection dryers are designed with different locations in which the equipment is installed, the air volume and the heat load of the heat exchange equipment are not the same, resulting in different types of fans, and there are numerous examples. In addition, the level of standardization and serialization of equipment is also relatively backward, and the interchangeability is poor, that is, the interchangeability of equipment produced by the same manufacturer is not satisfactory. Some foreign manufacturers compile numbers of all products of the factory. As long as the user asks which number of parts, they can provide exactly the same parts as the original. Users can easily maintain the equipment. The reliability of the parameters given in the specifications of many domestic manufacturers is not high, and the equipment specifications are too rough and incomplete, which increases the difficulty of user selection.
In terms of appearance, Chinese enterprises are even more difficult to pay attention to. On the other hand, the practice of enterprises in our country is to look at hard indicators, that is, equipment handling, work efficiency, and seldom look at the appearance. Second, domestically produced equipment often wins at low prices, making it difficult to add more value to the appearance, making it difficult to upgrade the appearance of the equipment.
3, the product has no characteristics, for the special needs of drugs, there is no corresponding solution
In the competition, homogeneity is the biggest drawback. In addition to some general equipment, special equipment is required for some special medicines. On the one hand, equipment companies need to actively consider the downstream pharmaceutical manufacturers. On the other hand, pharmaceutical manufacturers need to communicate with equipment companies. But this will inevitably increase the investment in technology research and development. In the small, scattered, and chaotic pharmaceutical equipment industry, only a few large companies can do it. Therefore, the industry reshuffle is inevitable.
For example, for drying equipment, there is a shortage of toxic drugs, high-temperature drugs, viscous drugs, flammable and explosive drugs, low-melting drugs, and other drugs that are drying in special requirements, which has become a constraint on domestic drying equipment to increase competitiveness and to go abroad. bottleneck.
With the further intensification of domestic competition in the pharmaceutical equipment industry, homogenization of products and backward technology have become increasingly clear. Foreign equipment is also plotting a vast market in China. Among internal and external troubles, only self-diagnosis and treatment can be carried out. After the pain, internal and external enhancements can be made to get out of the blue sky of pharmaceutical equipment in China.
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