US scientists discover microRNAs associated with autism
September 06, 2016 Source: US scientists discover microRNAs associated with autism
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; In a very important new study, scientists from UCLA in the United States found that brain tissue in patients with autism spectrum disorders had unique changes in the expression levels of some microRNAs. This study demonstrates the importance of microRNAs in autism disorders. The microRNAs found in this study regulate the expression of many genes known to be associated with autism.
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The relevant research results were published in the international academic journal Nature Neuroscience.
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In the study, the researchers examined the expression levels of nearly 700 microRNAs in brain tissue samples obtained at autopsy, including 55 autistic patients and 42 normal controls. The analysis focused on samples obtained from the cerebral cortex and found that there were 58 microRNA expression abnormalities, of which 17 were lower than normal and 41 were higher than normal.
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It is estimated that affected microRNAs can affect the expression of hundreds of different genes, a large part of which are already discovered autism risk genes, mutations or mutations in these genes are associated with autism, and some genes are There is no mutation but there is also abnormal activity in autistic patients. The researchers selected several of the microRNAs that are most strongly associated with autism, and experimentally confirmed that altering the expression levels of these microRNAs caused some changes in gene activity and the changes observed in brain tissue samples. Consistent.
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The study uses advanced RNA sequencing technology to reveal a few microRNAs related to autism that have never been reported before, one of which is specific in primates and not detected in mouse studies. The research team plans to conduct more detailed research on these microRNAs to better understand the effects of these microRNA changes on gene activity, brain development, cognition and behavior.
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The researchers said: "If you can artificially change the level of expression of these microRNAs in animal models of autism, observing whether you can reverse the characteristics of autism will be important for the future treatment of autism.
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