[China Pharmaceutical Network Science and Technology News] It is reported that Zheng Mingbin, a doctor of the School of Pharmacy of Guangdong Medical University, and Cai Lintao, a researcher at the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences, have made new breakthroughs in the homologous targeting of nano drug-loaded visualization and precision treatment of cancer. The new treatment for cancer treatment, the research results recently published in the top journal of the nano-field "ACSNano".
According to Zheng Mingbin, his research team constructed a polymer containing encapsulation of indocyanine green (ICG), a cancer cell membrane biomimetic nanoparticle (ICNPs), and was applied to the diagnosis and treatment of homologous MCF-7 breast cancer tumors. Adhesion molecules expressed on the membrane of cancer cells, such as epithelial cell adhesion molecules, neurocadmium, and galectin, can "localize" and "anchor" cancer cells with each other through receptor-ligand binding. Nano-particles "canopies" that penetrate cancer cells can adhere to membrane-adhesive molecules that recognize MCF-7 cancer cells, avoiding the effects of tedious chemical targeting modifications and potentially uncontrollable factors.
After the cancer cell membrane is coated, the nanoparticles not only disguise themselves, but also reduce the interception of liver and kidney, and finally achieve homologous targeted enrichment of MCF-7 tumors. Under the guidance of fluorescence/photoacoustic dual-mode imaging, near Infrared laser excitation, precise control of the local temperature of the tumor site, to achieve accurate treatment of cancer visualization." Zheng Mingbin said.
Zheng Mingbin said that the material of the outer layer of the nanoparticle phospholipid is the cancer cell membrane, which is extracted from the cancer cells in the tumor tissue; it uses the adhesion molecules on the outer layer of the particle to target the adhesion molecules of the same species or different species on the cancer cell. Thereby, the diagnosis of cancer cells is realized. Under the condition of laser illumination, the photosensitizer of the nanoparticles generates heat to kill the cancer cells; the tumor is derived from the tumor, and is applied to the tumor, thereby realizing "preventing cancer by cancer".
According to Zheng Mingbin, his research team constructed a polymer containing encapsulation of indocyanine green (ICG), a cancer cell membrane biomimetic nanoparticle (ICNPs), and was applied to the diagnosis and treatment of homologous MCF-7 breast cancer tumors. Adhesion molecules expressed on the membrane of cancer cells, such as epithelial cell adhesion molecules, neurocadmium, and galectin, can "localize" and "anchor" cancer cells with each other through receptor-ligand binding. Nano-particles "canopies" that penetrate cancer cells can adhere to membrane-adhesive molecules that recognize MCF-7 cancer cells, avoiding the effects of tedious chemical targeting modifications and potentially uncontrollable factors.
After the cancer cell membrane is coated, the nanoparticles not only disguise themselves, but also reduce the interception of liver and kidney, and finally achieve homologous targeted enrichment of MCF-7 tumors. Under the guidance of fluorescence/photoacoustic dual-mode imaging, near Infrared laser excitation, precise control of the local temperature of the tumor site, to achieve accurate treatment of cancer visualization." Zheng Mingbin said.
Zheng Mingbin said that the material of the outer layer of the nanoparticle phospholipid is the cancer cell membrane, which is extracted from the cancer cells in the tumor tissue; it uses the adhesion molecules on the outer layer of the particle to target the adhesion molecules of the same species or different species on the cancer cell. Thereby, the diagnosis of cancer cells is realized. Under the condition of laser illumination, the photosensitizer of the nanoparticles generates heat to kill the cancer cells; the tumor is derived from the tumor, and is applied to the tumor, thereby realizing "preventing cancer by cancer".
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