Recently, experts from the Comprehensive Experimental Research Center of Chongqing Southwest Hospital discovered that graphene is helpful for early diagnosis of tumors. The research results have been published in the international authoritative journal Analytical Chemistry, which is of great significance for the early diagnosis and treatment of various tumors.
Clinically, most tumors are often found late. Conventional tumor detection methods such as B-ultrasound, X-ray, and CT have limited sensitivity and are radioactive, and are not suitable for early screening of tumors in the general population. The humoral tumor markers are currently the most ideal non-invasive screening method in the clinic, but the related humoral tumor markers are often produced when the tumor has developed to maturity.
"To solve the problem of early detection of tumors, we must find the detection target from an earlier molecular level in the early stage of abnormality in the body." Research team member Qiu Xiaopei said that when the nucleic acid molecule biomarker cmocroRNA is abnormal in the body, it The content will also change. After repeated trials, the team found cmocroRNA in serum, urine and saliva.
Qiu Xiaopei introduced that the presence of cmocroRNA is only the first step. In the early stage of tumor, the cmocroRNA released from the body to the blood and urine is extremely small. It is difficult to detect common nucleic acid detection methods. The research team focused on DNAase, a specific nuclease that amplifies the detection signal by "infinite loop digestion", and the signal amplification is based on a very large number of probes. To this end, they introduced a highly adsorbable graphene, which increased the number of captured cmocroRNA probes by a factor of 10, greatly improving the sensitivity of detection, and finally capturing cmocroRNA.
According to reports, through the comprehensive analysis of the captured cmocroRNA, it can be concluded whether the body has cancer and which kind of cancer, is of great significance for the early diagnosis and treatment of various types of tumors. At present, the research has entered the research stage of the kit and is expected to be applied to the clinic within two or three years.
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