In late June, it was reported that in the case of an Indonesian family of eight people who died of bird flu, WHO (World Health Organization) for the first time found evidence of human flu of the bird flu virus. The reporter did not find the relevant report when he visited the WHO website. He also asked the officials of the WHO office in Beijing that he had not received a positive reply.
Researcher Guo Yuanji, head of the influenza prevention and control expert group of the Ministry of Health, pointed out at the national flu epidemic trend and prevention seminar held in Nanjing recently that there is still no evidence that the bird flu virus has human-to-human abilities and there is no evidence that it Have the ability to infect people. As of now, human cases of bird flu are still only incidents.
The direct infection of bird flu virus does not occur in nearly 10 years
Guo Yuanji said that since the outbreak of the H5N1 bird flu virus in the Hong Kong SAR in 1997, there have been international concerns that the H5N1 bird flu virus could trigger a pandemic worldwide. Some reports that have caused the public to panic continue to be published. “The defense against major infectious diseases is based on the most serious situation, but it must be scientifically evaluated and scientifically evaluated for the actual epidemic. Do not shout 'Wolf Comes' every day. Instead, learn the lessons of the 'Wolf's coming.' â€
Guo Yuanji pointed out that the case of direct infection of humans by the bird flu virus did not begin in 1997. In the 1950s, humans had discovered cases of direct infection of human H7N7 subtype strains. Since then, incidents of direct infection of humans with the bird flu virus have been reported in many countries and regions, and the bird flu virus that directly infects humans includes multiple strains of subtypes.
Guo Yuanji believes that although cases of H5N1 flu have been reported in Vietnam, Thailand, Cambodia, Laos, Indonesia, China, Turkey, Azerbaijan, Djibouti, Egypt and Iraq since the end of 2003, it is not certain that the next human flu will be large. The epidemic is caused by avian H5N1 subtype strains, and when and where it occurs is unknown.
H5N1 virus does not yet have human biological basis
According to statistics, since 2003, there has been a severe outbreak of bird flu among animals in many parts of the world, and as of now, there are only 200 cases of human bird flu reported worldwide. Guo Yuanji said that in the close contact between large groups of people and dead and dead birds, why are those infected? Because of the series mechanism of the species barrier, it plays a role.
Guo Yuanji told reporters that there is a clear difference in receptor specificity between human and bird flu viruses, and human respiratory epithelial cells contain almost no receptors for bird flu viruses. On the highly pathogenic avian H5N1 influenza virus HA protein molecule, the linker peptide between the heavy chain (HA1) and the light chain (HA2) contains a string of basic amino acids, whereas the human influenza virus contains only one basic amino acid. The H5N1 avian influenza virus genome isolated from human bird flu cases in the world today does not contain a human influenza virus gene segment and thus is different from human influenza virus. This suggests that the H5N1 virus does not yet have the human biological basis.
The mystery of the origin and spread of H5N1 is far from unveiled
Guo Yuanji pointed out that the scientific community’s role in the transmission of H5N1 and lower animals in the spread of bird flu is still limited to preliminary understanding. Many of these mysteries are far from being revealed. Guo Yuanji expressed different opinions on some viewpoints of related reports in recent years.
Guo Yuanji believes that migratory birds certainly played a role in the transmission of the bird flu virus, but the bird flu outbreak was blamed on migratory birds each time. There is insufficient evidence. The reason is that the migration of migratory birds has strict seasonality and routes, and the timing and location of the outbreak of bird flu does not completely coincide with it. For example, from Russia, Kazakhstan, Iraq, and Turkey, the outbreak of H5N1 strain in poultry was found to be a similar strain of spotted goose in Qinghai Lake. The Qingtou Lake spotted goose was suspected of being the source of all H5N1 virus strains. In this regard, Guo Yuanji believes that Qinghai Lake is located in the northwest of China, which is irrelevant to the migration time and path of spotted geese. Moreover, the H5N1 strain is a lethal virus against the spot-headed geese. If an H5N1 virus infection occurs, the spot-headed geese may die and may not fly to Qinghai Lake. The recently published genetic analysis showed that the strain of Qinghai Lake was very far from the H5N1 strain isolated from Chinese people, but it was similar to that of the Turks. The genetic characteristics of H5N1 strains isolated from humans in China, Hong Kong SAR, Thailand, Vietnam, and Indonesia are quite different and have regional differences.
There have been two speculations about the source of the highly pathogenic avian influenza virus H5N1 since 1997: either from a non-dominantly infected bird or from a less pathogenic H5N1. Guo Yuanji believes that the former is more likely than the latter.
Guo Yuanji disclosed that academics have the opinion that pigs are the tomb of the human flu virus. It is generally believed that if the H3N2 subtype influenza virus infects pigs, it will not be transmitted back to humans by the pigs. There was also research on experimental infection of pigs with the H5N1 virus. It was found that the pigs were not very sensitive to the H5N1 strain and pigs were not allowed to pass through the pigs. As of now, no human bird H5N1 flu has been transmitted to humans through pigs.
Preventing human bird flu will be a protracted war
Guo Yuanji suggested that the current research on human bird flu vaccine should focus on establishing a new platform for vaccine preparation and actively develop a reserve of research and development technologies rather than a physical reserve. To develop a vaccine to use domestic representative strains. At the same time, we must fully understand the flu virus's variable nature and use a dynamic eye to see today's anti-influenza virus drugs.
“Humans are unlikely to eliminate the H5N1 flu virus from poultry in the short term. Human cases of bird flu will continue to occur occasionally and should be highly valued, but we must not blindly panic. The current priority is to do a solid job. The monitoring work must be prepared for long-term combat in defense and must not be dealt with in a fast-paced manner, said Guo Yuanji.
Researcher Guo Yuanji, head of the influenza prevention and control expert group of the Ministry of Health, pointed out at the national flu epidemic trend and prevention seminar held in Nanjing recently that there is still no evidence that the bird flu virus has human-to-human abilities and there is no evidence that it Have the ability to infect people. As of now, human cases of bird flu are still only incidents.
The direct infection of bird flu virus does not occur in nearly 10 years
Guo Yuanji said that since the outbreak of the H5N1 bird flu virus in the Hong Kong SAR in 1997, there have been international concerns that the H5N1 bird flu virus could trigger a pandemic worldwide. Some reports that have caused the public to panic continue to be published. “The defense against major infectious diseases is based on the most serious situation, but it must be scientifically evaluated and scientifically evaluated for the actual epidemic. Do not shout 'Wolf Comes' every day. Instead, learn the lessons of the 'Wolf's coming.' â€
Guo Yuanji pointed out that the case of direct infection of humans by the bird flu virus did not begin in 1997. In the 1950s, humans had discovered cases of direct infection of human H7N7 subtype strains. Since then, incidents of direct infection of humans with the bird flu virus have been reported in many countries and regions, and the bird flu virus that directly infects humans includes multiple strains of subtypes.
Guo Yuanji believes that although cases of H5N1 flu have been reported in Vietnam, Thailand, Cambodia, Laos, Indonesia, China, Turkey, Azerbaijan, Djibouti, Egypt and Iraq since the end of 2003, it is not certain that the next human flu will be large. The epidemic is caused by avian H5N1 subtype strains, and when and where it occurs is unknown.
H5N1 virus does not yet have human biological basis
According to statistics, since 2003, there has been a severe outbreak of bird flu among animals in many parts of the world, and as of now, there are only 200 cases of human bird flu reported worldwide. Guo Yuanji said that in the close contact between large groups of people and dead and dead birds, why are those infected? Because of the series mechanism of the species barrier, it plays a role.
Guo Yuanji told reporters that there is a clear difference in receptor specificity between human and bird flu viruses, and human respiratory epithelial cells contain almost no receptors for bird flu viruses. On the highly pathogenic avian H5N1 influenza virus HA protein molecule, the linker peptide between the heavy chain (HA1) and the light chain (HA2) contains a string of basic amino acids, whereas the human influenza virus contains only one basic amino acid. The H5N1 avian influenza virus genome isolated from human bird flu cases in the world today does not contain a human influenza virus gene segment and thus is different from human influenza virus. This suggests that the H5N1 virus does not yet have the human biological basis.
The mystery of the origin and spread of H5N1 is far from unveiled
Guo Yuanji pointed out that the scientific community’s role in the transmission of H5N1 and lower animals in the spread of bird flu is still limited to preliminary understanding. Many of these mysteries are far from being revealed. Guo Yuanji expressed different opinions on some viewpoints of related reports in recent years.
Guo Yuanji believes that migratory birds certainly played a role in the transmission of the bird flu virus, but the bird flu outbreak was blamed on migratory birds each time. There is insufficient evidence. The reason is that the migration of migratory birds has strict seasonality and routes, and the timing and location of the outbreak of bird flu does not completely coincide with it. For example, from Russia, Kazakhstan, Iraq, and Turkey, the outbreak of H5N1 strain in poultry was found to be a similar strain of spotted goose in Qinghai Lake. The Qingtou Lake spotted goose was suspected of being the source of all H5N1 virus strains. In this regard, Guo Yuanji believes that Qinghai Lake is located in the northwest of China, which is irrelevant to the migration time and path of spotted geese. Moreover, the H5N1 strain is a lethal virus against the spot-headed geese. If an H5N1 virus infection occurs, the spot-headed geese may die and may not fly to Qinghai Lake. The recently published genetic analysis showed that the strain of Qinghai Lake was very far from the H5N1 strain isolated from Chinese people, but it was similar to that of the Turks. The genetic characteristics of H5N1 strains isolated from humans in China, Hong Kong SAR, Thailand, Vietnam, and Indonesia are quite different and have regional differences.
There have been two speculations about the source of the highly pathogenic avian influenza virus H5N1 since 1997: either from a non-dominantly infected bird or from a less pathogenic H5N1. Guo Yuanji believes that the former is more likely than the latter.
Guo Yuanji disclosed that academics have the opinion that pigs are the tomb of the human flu virus. It is generally believed that if the H3N2 subtype influenza virus infects pigs, it will not be transmitted back to humans by the pigs. There was also research on experimental infection of pigs with the H5N1 virus. It was found that the pigs were not very sensitive to the H5N1 strain and pigs were not allowed to pass through the pigs. As of now, no human bird H5N1 flu has been transmitted to humans through pigs.
Preventing human bird flu will be a protracted war
Guo Yuanji suggested that the current research on human bird flu vaccine should focus on establishing a new platform for vaccine preparation and actively develop a reserve of research and development technologies rather than a physical reserve. To develop a vaccine to use domestic representative strains. At the same time, we must fully understand the flu virus's variable nature and use a dynamic eye to see today's anti-influenza virus drugs.
“Humans are unlikely to eliminate the H5N1 flu virus from poultry in the short term. Human cases of bird flu will continue to occur occasionally and should be highly valued, but we must not blindly panic. The current priority is to do a solid job. The monitoring work must be prepared for long-term combat in defense and must not be dealt with in a fast-paced manner, said Guo Yuanji.
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