Cervical cancer is the second most common malignant tumor in women. In recent years, its incidence has become younger. The isomeric compounds TAD-1822-7-F2 (F2) and TAD-1822-7-F5 (F5) designed based on the chemical structure of taspine and its derivatives can effectively inhibit the proliferation of HeLa cells. Researchers at Xi'an Jiaotong University used OpenSPR's surface plasmon resonance (SPR) technology to delve into the intrinsic mechanisms by which F2 and F5 inhibit Hela cell proliferation. The study "Novel compounds TAD-1822-7-F2 and F5 inhibited HeLa cells growth through the JAK/Stat signaling pathway" was published in "Biomedicine & Pharmacotherapy" in May 2018.
The JAK/STAT pathway is closely related to the development of tumors. Previous studies have found that F2 and F5 inhibit the proliferation of Hela cells. To investigate whether the inhibitory mechanisms of F2 and F5 are related to JAK2 protein, this study used Nicoya's OpenSPR to detect the interaction between F2/F5 and JAK2. The protein was immobilized on the NTA chip, and then different concentrations of F2/F5 were passed through the chip, and the kinetic parameters were analyzed. It was found that both F2/F5 and JAK2 have strong affinity, and the molecular target of F2/F5 inhibiting cancer cell proliferation was quickly determined.
SPR is a label-free detection technique that quantifies the binding between two molecules and determines the rate constant, the dissociation rate constant, and the affinity of the intermolecular interactions. Compared with the traditional ELISA, pull-down and other end-point detection techniques, SPR technology has the advantages of simple operation, real-time observation and rich data. In recent years, the literature published using SPR technology has grown significantly.
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Advantages of Nicoya OpenSPR Molecular Interaction in Cancer Research:
• Easy to operate - 1 hour to control;
• Complete kinetic parameter detection --- Ka, Kd, ​​KD;
• High efficiency --- loading, results, one-click analysis, results in 10min, complete kinetic test results in 1-2h;
• High precision --- detection is not affected by temperature and buffer refractive index;
• No special correction channel required - negligible bulk effect;
Pain Relief Patch For Neck Shoulder,Lower Back And Leg
Pain Relief Patch for neck shoulder, lower back and leg.
[Name] Medical Cold Patch
[Package Dimension] 10cm×12cm 2pieces/box
The pain relief patch is composed of three layers, namely, backing lining, middle gel and protective film. It is free from pharmacological, immunological or metabolic ingredients.
[Scope of Application] For cold physiotherapy, closed soft tissue only.
[Indications]
The patches give fast acting pain relief for strains, sprains, cramp, bruises, swollen areas or joint stiffness.
[How To Use a Patch]
Tear off the packaging bag and remove the patch. Remove the protective film and apply the patch on the skin. One piece, one time. The curing effect of each piece can last for 8-12 hours.
[Attention]
Do not apply the patch on the problematic skin, such as wounds, eczema, dermatitis,or in the eyes. People allergic to herbs and the pregnant are advised not to use the medication. If swelling or irritation occurs, please stop using and if any of these effects persist or worsen.notify your doctor or pharmacist promptly. Children using the patch must be supervised by adults.
[Storage Conditions]
Store below 30c in a dry place away from heat and direct sunlight.
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