The anti-cancer power of nanoparticles for injection is "amazing"!
March 28, 2016 Source: Kexun
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)]; A few decades ago, the idea of ​​developing any type of nanoscale solution was just a dream.
The term "nanotechnology" was first publicly published in 1986.
The control, development, and use of this small thing with only 1/100,000 of human hair has changed from science fiction to scientific facts.
Today, nanoparticles help golf balls fly straighter, make bowling surfaces more durable, and extend the life of exterior wall paint.
Nanoparticle technology has been widely used in industry and manufacturing, but their potential use in the medical field is also being tested; for example, the design of a bandage implanted with silver nanoparticles helps the wound heal faster.
Among the potential medical applications of nanotechnology, the most important are targeted drug delivery systems for combating various diseases including cancer.
Current anticancer drug delivery
The metastasis of lung cancer and liver cancer is the leading cause of cancer death. In many cases, the role of existing anticancer drugs is limited because the body itself has a protective biological barrier. These chemicals do not reach high enough concentrations at the intended target and can spread to healthy tissues, causing serious side effects.
Mauro Ferrari, President and CEO of the Houston Methodist Institute in Houston, has been working in nanomedicine for 20 years, and his latest research provides the most impressive results to date.
Ferrari and his research team have developed a mechanism by which nanoparticles can pass through these biological barriers and, once inside the tumor, release toxic chemicals that act directly on the tumor core.
Nanoparticle generator for injection
The team used an injectable nanoparticle generator (iNPG) that was encapsulated into a polymer light chain by the active drug doxorubicin into a nanoporous silicon material.
Once the nanoparticle generator for injection (iNPG) enters the tumor, the silicon outer coating naturally degrades, releasing the polymer chain. The chain curls into nano-sized pellets and enters the cancer cells themselves. The small ball moves freely within the cancer cell and approaches the nucleus, and the pH decreases. The reduced pH triggers the release of doxorubicin from the polymer chain, killing cancer cells.
Nanoparticle generators for injection (iNPG) have been tested in triple-negative breast cancer mice that have metastasized to lung tissue. Triple-negative breast cancer accounts for about one-tenth of all breast cancers. They are particularly difficult to treat and do not respond to hormone therapy.
“Our findings are revolutionaryâ€
Although the prognosis of triple-negative breast cancer is poor, Ferrari and his team found that 50% of mice treated with the nanoparticle generator for injection (iNPG) showed no signs of metastasis after 8 months. It is considered to be equivalent to 24 years of humanity.
Ferrari said:
"It may sound like science fiction, just as we have penetrated and destroyed the Star of Death, but our discovery is definitely a major change. We have invented a method that does allow nanoparticles to enter cancer cells, and Release drug particles at the location of the nucleus."
The researchers are extremely satisfied with these results and hope that they will bring new dawn to medical intervention. Any progress in treating this intractable disease is completely welcome.
“With nano-injectors for injection, we can do standard chemotherapy drugs, vaccines, radiation therapy and other nanoparticles,†the authors said. The Houston Methodist Institute hopes to quickly track the study and as soon as possible. Obtained approval from the FDA (US Food and Drug Administration). They plan to conduct human trials of the drug in 2017.
Although it is hoped that it will always be keen to hold this result correctly and not expect too much, in private, Ferrari has a hard time maintaining its enthusiasm:
“I would never want to promise thousands of cancer patients to find a cure, but the test data is a big surprise. We are talking about changing the prospects for treating metastatic disease because it is no longer sentenced to death. It is."
Ferrari's excitement, we all feel the same, understandable. Even if future conclusions are drawn in human subjects, survival is only a small fraction of the results of this study, and the results will be considered a huge success.
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