Bodybuilding White Lyophilized Peptide Hormone Follistatin 344

Detail
Name: Follistatin 344
Synonyms: FST, FS, Activin-binding protein.
Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Manufacturer: Quanao
Purity (by HPLC): 99.00%
Source: Escherichia Coli
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a concentrated (1mg / ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18MΩ-cm H2O not less than 100μg / ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized Follistatin although stable at room temperature for 3 weeks.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE..
Storage Conditions: Aviod Shunshine and Keeping Stoppered
Packing: 1mg / vial, 2mg / vial


Description
Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene.Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.

Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone. An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).
 
Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.

A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.
 

 

Applications

Follistatin-344 significantly increases growth and strength of muscles by blocking Myostatin (GDF-8-a protein inhibiting muscle growth). Follistatin-344 seems to be a very promising Myostatin inhibitor, possessing a sufficient safety profile.
 
Follistatin-344 is also a perfect choice for those sportsmen who cannot exercise on a regular basis any longer or for those who stopped exercising, but they still want to stay in shape, having a huge muscle mass. It has been proved, that the less strenuous muscle load and the less physical activity is, the higher concentration of Myostatin is reached.
 
Follistatin-344 is an autocrine glycoprotein encoded by the FST gene that is expressed in nearly all tissues. Its primary function in the body is bioneutralization of members of the TGF-β superfamily, with a particular focus on activin and paracrine hormones. Follistatin is a potent Moystatin inhibitor. An original Follistatin acted also as an activin inhibitor, which on the other hand stimulates the secretion of follicle-stimulating hormone - FSH (activin regulates the growth and differentiation of all cell types, including cells within sexual glands, pituitary gland and skeletal muscles). Therefore, scientists developed a particular Follistatin (Follisttain-344) that is derived from the original one and that is capable of blocking preferentially Moystatin activity.
 
The Follistatin-344 peptide has also a substantial effect on the tissue rejuvenation. Its significant anti-aging effect is comparable to the one delivered by Melatonin or other peptides that play a positive role in the anti-aging process.

COA Detail
Name: Follistatin 344
Synonyms: FST, FS, Activin-binding protein.
Appearance: Sterile Filtered White Lyophilized (Freeze-Dried)
Manufacturer: Quanao
Purity (by HPLC): 99.00%
Source: Escherichia Coli
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a concentrated (1mg / ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18MΩ-cm H2O not less than 100μg / ml, which can then be further diluted to other aqueous solutions.
Stability: Lyophilized Follistatin although stable at room temperature for 3 weeks.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.
Purity: Greater than 95.0% as determined by (a) Analysis by RP-HPLC (b) Analysis by SDS-PAGE..
Storage Conditions: Aviod Shunshine and Keeping Stoppered
Packing: 1mg / vial, 2mg / vial


Description
Follistatin also known as activin-binding protein is a protein that in humans is encoded by the FST gene.Follistatin is an autocrine glycoprotein that is expressed in nearly all tissues of higher animals.

Its primary function is the binding and bioneutralization of members of the TGF-β superfamily, with a particular focus on activin, a paracrine hormone. An earlier name for the same protein was FSH-suppressing protein (FSP). At the time of its initial isolation from follicular fluid, it was found to inhibit the anterior pituitary's secretion of follicle-stimulating hormone (FSH).
 
Follistatin is being studied for its role in regulation of muscle growth in mice, as an antagonist to myostatin (also known as GDF-8, a TGF superfamily member) which inhibits excessive muscle growth. Lee & McPherron demonstrated that inhibition of GDF-8, either by genetic elimination (knockout mice) or by increasing the amount of follistatin, resulted in greatly increased muscle mass.In 2009, research with macaque monkeys demonstrated that regulating follistatin via gene therapy also resulted in muscle growth and increases in strength. This research paves the way for human clinical trials, which are hoped to begin in the summer of 2010 on Inclusion body myositis.

A study has also shown that increased levels of follistatin, by leading to increased muscle mass of certain core muscular groups, can increase life expectancy in cases of spinal muscular atrophy (SMA) in animal models.It is also being investigated for its involvement in polycystic ovary syndrome (PCOS), though there is debate as to its direct role in this infertility disease.
 

 

Applications

Follistatin-344 significantly increases growth and strength of muscles by blocking Myostatin (GDF-8-a protein inhibiting muscle growth). Follistatin-344 seems to be a very promising Myostatin inhibitor, possessing a sufficient safety profile.
 
Follistatin-344 is also a perfect choice for those sportsmen who cannot exercise on a regular basis any longer or for those who stopped exercising, but they still want to stay in shape, having a huge muscle mass. It has been proved, that the less strenuous muscle load and the less physical activity is, the higher concentration of Myostatin is reached.
 
Follistatin-344 is an autocrine glycoprotein encoded by the FST gene that is expressed in nearly all tissues. Its primary function in the body is bioneutralization of members of the TGF-β superfamily, with a particular focus on activin and paracrine hormones. Follistatin is a potent Moystatin inhibitor. An original Follistatin acted also as an activin inhibitor, which on the other hand stimulates the secretion of follicle-stimulating hormone - FSH (activin regulates the growth and differentiation of all cell types, including cells within sexual glands, pituitary gland and skeletal muscles). Therefore, scientists developed a particular Follistatin (Follisttain-344) that is derived from the original one and that is capable of blocking preferentially Moystatin activity.
 
The Follistatin-344 peptide has also a substantial effect on the tissue rejuvenation. Its significant anti-aging effect is comparable to the one delivered by Melatonin or other peptides that play a positive role in the anti-aging process.

COA

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