Every year, many people worldwide die from surgery and implant-related infections. Antibiotics have been the only response in the medical world for many years. However, under normal circumstances, oral, injection, direct injection of the appropriate dose of antibiotics does not safely cover the entire area, or the duration is relatively short.
Recently, a Canadian company called Orthopaedic Innovation Center came up with a solution and filed a patent application accordingly. This patent is a process for making antimicrobial articles for implants by additive manufacturing techniques.
The process is mainly to inject antibiotics or other antibacterial drugs during the printing process when 3D printing medical implants. The following is a description of the process:
"An antibiotic-eluting article that can be implanted into a mammalian subject, which is produced by an additive manufacturing process in which the polymeric material is deposited simultaneously with a selected antibiotic. The additive manufacturing method may be a fused deposition molding (FDM) technique, a selective laser sintering (SLS) technique, a selective heating sintering technique, a digital light processing (DLP) technique, or a stereolithography (SLA) technique. The article may be a temporary or permanent orthopedic bone component, an arthroplasty component of an orthopedic joint, and/or an outer hard outer casing of an implantable device."
This patent covers a variety of technologies for additive manufacturing, including fused deposition (FDM) and laser sintering (SLS). So how are they implemented?
For example, FDM technology: When manufacturing wires for FDM3D printers, antibiotics can be mixed with PLA or PCL polymer pellets to make antibiotic-containing wires. PLA and PCL are absorbable materials, which means that they will decompose in mammals over time. The doctor can determine the amount of antibiotics when making the wire and can add more than one antibiotic. Once the "fed" 3D printed wire is ready, it can be printed into an implant of any shape and size.
A similar approach can be used with other printing technologies. For example, researchers can use selective laser sintering (SLS) to mix particles made of plastic, metal, ceramic or glass with antimicrobial agents as a laser-melted material.
Selective laser sintering is formed using a powdered material. Spread the material powder on the upper surface of the formed part and flatten it; use a high-strength CO2 laser to scan the cross section of the part on the freshly laid layer; the material powder is sintered together under high-intensity laser irradiation to obtain The section of the part is bonded to the formed part below; when the section is sintered, a new layer of material powder is applied and the lower section is selectively sintered. The biggest advantage of the SLS process is the wide selection of materials such as nylon, wax, ABS, resin coated sand (coated sand), polycarbonates, metal and ceramic powders.
The discovery also includes the addition of bone growth material to the print, which allows for the simultaneous addition of anti-infectives and bone growth promoting substances. This makes the technique suitable for surgery involving bones. Such implants can also play a vital role in other medical applications, including chemotherapy, infusion pumps, pacemakers, and the like.
Organic Spirulina powder is a biomass of cyanobacteria (blue-green algae) that can be consumed by humans and animals.Organic Spirulina used as a dietary supplement or whole food. It is also used as a feed supplement in the aquaculture, aquarium, and poultry industries.Dried spirulina powder contains 5% water, 24% carbohydrates, 8% fat, and about 60% proteinSpirulina powder, as nutrient-rich dietary supplement, supplies calories and is a rich source of numerous essential nutrients,particularly protein, B vitamins (thiamin, riboflavin, and niacin ), and dietary minerals, such as iron and manganese.Providing the fatty acids, gamma-linolenic acid, alpha-linolenic acid, linoleic acid, stearidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid.
Spirulina Powder,Organic Spirulina Powder,Pure Spirulina Powder,Organic Pure Spirulina Powder
XI'AN PLANT BIO-ENGINEERING CO.,LTD , https://www.plantbic.com