Nanoparticles achieve new targeting system for anticancer drugs

Release date: 2016-02-22

The purpose of chemotherapy is to kill cancer cells, rather than letting patients lose their hair. A new molecular delivery system created by Canadian scientists has ensured that chemotherapeutic drugs reach their targets while minimizing collateral damage.

Many anticancer drugs target fast-growing cells, and after being injected into a patient, the drug cruises around the blood before it acts. But unfortunately, these cells include hair follicles, the inner wall of the digestive tract, and the skin in addition to tumors.

The research team led by Professor Chen Zhihe from the Institute of Biomaterials and Biomedical Engineering at the University of Toronto has recently designed a set of nanoparticles that can be attached to DNA (deoxyribonucleic acid) chains that change shape to reach the lesion.

Professor Chen Zhihe explained that the human body is like an apartment, and there are many rooms in the apartment. To move something into a particular room, you first have to map a map and then develop a system that can be shuttled through the house. Each path of the system can reach a target room with different limits (such as height and width). He said that no two tumors are identical. For example, the treatment effect of a specific treatment regimen on early breast cancer is different from that of pancreatic cancer, and even the treatment effect of breast cancer in the middle and late stages is different. Which drug particles can reach the inside of the tumor depends on various factors such as particle size, shape and surface chemistry.

The research team published a paper in the latest issue of the Proceedings of the National Academy of Sciences and Science, saying that they studied how these factors affect the delivery of small molecules to tumors, and ultimately designed a modular nanoparticle. A targeted molecule delivery system in which the shape, size and chemical properties of the nanoparticles can be altered by a particular DNA sequence. This deformable nanoparticle is like a Lego brick that can be constructed in a number of shapes that can be exposed or hidden in conjunction with points. By changing the shape like a key to open a lock, it can respond to biomolecules.

These shape converters consist of tiny metal blocks with attached DNA strands. The nanoparticles will float harmlessly in the bloodstream until a DNA strand binds to a DNA sequence representing a cancer marker. At this point, the nanoparticles begin to change shape and then perform their function: positioning the cancer cells, releasing the drug molecules into the cancer cells, and labeling the cancerous cells with signaling molecules.

Source: Technology Daily

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