The Massachusetts Institute of Technology (MIT) official website announced on the 14th that the school's research team has overcome a major technical problem in synthetic biology: separating different genetic lines into a single synthetic cell to prevent them from interfering with each other. Concatenate into more complex genetic lines to synthesize more complex drug molecules. This new approach can help researchers design new genetic lines and help unravel the mystery of the early origins of life on Earth.
The research team published a paper in the journal Nature and Chemistry, saying that they wrapped genetic lines in liposome droplets. These liposomes possess a fat membrane that is very similar to the cell membrane and can act as an artificial cell, in addition to recognizing DNA. There is no other cellular function than synthetic proteins. Edward Boyton, associate professor of bioengineering and brain cognition science at the school, said: "Liposomes build a 'wall' between genetic lines so that they can't communicate with each other, even if they live in the same cell factory, they won't interact with each other. interference."
The research team also demonstrated that the method can be used to generate complex lines containing genetic lines from different organisms. They exposed artificial cells containing bacterial genetic lines to theophylline molecules, inducing doxycycline molecules, a drug that treats upper respiratory tract infections, to leave the liposomes and enter liposomes containing mammalian genetic lines. Polycyclic cyclin activates the genetic material to produce the fluorescent protein, luciferase. Boyton explained: "In a mixed-line system composed of bacterial genetic material and mammalian genetic material, the bacterial line is like a computer program, and the mammalian line is more like a factory. When the two combine, they induce molecules emitted by brain cells or other cells. Signals can generate complex biological drugs such as antibodies."
The researchers also inserted a protein called "SNAREs" into the surface of the liposome's fat membrane, where different liposomes fuse together. By grasping the timing of the fusion of these liposomes, the molecules they produce can be combined into the desired end product.
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