Release date: 2017-03-30
Although the radioactive iodine 125 particles are less than 1mm in diameter and less than 5mm in length, many precise distributions are implanted into the tumor to gather and detonate from the inside to the outside, which can effectively treat solid tumors. Combined with the stent technology, it can also achieve the dual effect of opening narrow passages and "cofferdam" tumors. This magical "artifact" is small but powerful. Recently, the Zhongda Hospital affiliated to Southeast University came to the news. As one of the “Ace Technology†at home and abroad, Zhongda Hospital Intervention and Vascular Surgery Teng Yijun, Guo Jin and team experts showed iodine particles and stents to colleagues in and outside the province. Combined with 3D printing and other applications to treat the magical charm of the tumor.
Case: Iodine particles array three times to completely eliminate tumor lesions
Although the iodine 125 particles are very small and gather together, you should not underestimate it. Some time ago, it can eliminate a huge osteosarcoma. The 80-year-old Zhang Laojiao is the beneficiary. A year ago, after Zhang Laojiao walked, he developed a painful soreness in his left lower limb, and he could only walk a few steps. After going to the Zhongda Hospital for nuclear magnetic resonance, biopsy and other related examinations, it was found to be left hip osteosarcoma. The lesion was actually 10.4cm*8.0cm, and there was no indication for surgery. At the time of the fundraising, Dr. Zhu Guangyu, deputy chief physician and Dr. Wang Yong from the team of Guo Jinhe and the director of vascular surgery, gave him hope. 
3D print template for iodine particle implantation
Due to the large size of the lesion, too many iodine particles cannot be implanted at one time and can only be carried out step by step. In March last year, Zhang Laojiao implanted iodine particles for the first time. 120 granules were distributed in his lesions. The particles entered the "enemy" and slowly consumed the "enemy gods" for half a year. In September 2016, the second squad 90 granules sent troops. After two months, the force was replenished for the third time, and the remnants of the "encirclement and suppression". Recently, a good news came, and Zhang Laojiao was admitted to the hospital again and found that the lesions were gone, and the biological activity of the tumor disappeared. Zhang Laojiao also clearly felt that "it is like a healthy person, and finally can walk away with crutches."
Array method: precise placement of particles
How do iodine particles fight? Director Guo Jinhe introduced the accurate location of the tumor site by CT or B-ultrasound. Fine radioactive iodine particles are implanted into the tumor tissue after puncture under image guidance. According to the size and location of the tumor, the diseased tissue is directly irradiated, and the tumor cells are directly irradiated.
It is reported that the power of iodine particles lies in the radioactivity, releasing gamma rays, but it is a low-energy ray. A large number of iodine particles are distributed inside the tumor, with a half-life of 60 days, and radiation disappears for 200 days. The tumor is effectively treated within the two months to half a year, and eventually the tumor collapses. Iodine particles are suspected of tumor killing, but the damage to surrounding normal tissue is very small.
Benefits: More than 2,000 patients with cancer in 14 years became beneficiaries
The radioactive iodine particle technology has been in the hospital for 14 years, and more than 2,000 patients have become the beneficiaries of the iodine particles fighting the tumor. What are the common characteristics of these patients, and what kind of tumor is the main target of iodine particles? Guo Jinhe said that iodine particle implantation is currently aimed at prostate cancer, lung cancer, liver cancer and solid tumors that are rare in clinically difficult and complex solid tumors or in the retroperitoneal, pelvic and vertebral attachments. Especially for surgical treatment is not ideal, radiotherapy and chemotherapy is not sensitive to synovial sarcoma, leiomyosarcoma, rhabdomyosarcoma, malignant histiocytoma, malignant schwannomas and other solid tumors.
The first: the carrier-loaded particles are more powerful
I am good at studying iodine particles, and I also learned to use external forces to ride on the scooter to fight cancer and upgrade. The stent can be opened to “drain the tube†and local radiotherapy to prevent tumor growth.
This time, its array method is also carried out step by step. The stent loaded with iodine particles is sent to the lesion first. The open part of the stent causes the iodine particles to temporarily "fall" at the lesion; the second step is to wear the real stent. At the center of the rolled up "barbed wire", this bracket can act as a true opening, both to narrow the narrow area and to allow the iodine particles to "stand firm" at the plug.
Professor Teng Junjun, a well-known interventional medicine expert and president of Zhongda Hospital, introduced that particle scaffolding technology was pioneered by Zhongda Hospital at home and abroad. Iodine particles can be implanted directly into patients, and advanced and effective treatment can be provided for patients through particle scaffolds. The scaffold is the carrier of the particles, which can open the narrow cavity of the patient and play a therapeutic role in ensuring that the normal function of the patient's organs is not affected. The most common radioactive esophageal stent is a local internal irradiation treatment for tumors while solving dysphagia. At present, radiation particle stent technology has been applied from esophageal extension to biliary obstruction, tracheal stenosis, advanced portal vein tumor thrombus treatment, and treatment of inferior vena cava tumor thrombus.
Innovation: 3D printing template + iodine particles implanted with double swords
Zhongda Hospital's intervention and vascular surgery iodine particle implantation technology continues to innovate, taking the lead in adopting advanced 3D printing technology in East China, making the combat array against solid tumors more precise.
“When there is no 3D template, the doctor judges the location of the lesion by CT layer by layer and multiple scans. With 3D printing technology, the positioning is three-dimensional, and the accurate calculation effectively avoids blood vessels, nerves and bones.†Guo Jinhe introduced, 3D printing Good template, how the particles are arranged at a glance. During the operation, the doctor only needs to display according to the template, the accuracy of the control and operation is improved, the puncture positioning time is shortened, and the operation time is also shortened accordingly.
United: Multi-armed operations combined against cancer
Guo Jinhe pointed out that although the iodine particles are powerful, they have combined with other treatment methods and their combat power has increased. Iodine particle implantation is also used in conjunction with other interventional methods to combat tumors. For example, for the treatment of intrahepatic cholangiocarcinoma, the tumor is first scalded by microwave ablation, followed by particle implantation.
The treatment of tumors also requires multidisciplinary integration. Experts from various disciplines evaluate and diagnose from various fields, and then propose systematic treatment plans. In general, early liver cancer is suitable for surgical treatment and ablation; advanced liver cancer is treated with interventional therapy; advanced liver cancer is suitable for molecular targeted drug therapy and supportive therapy. Multidisciplinary cooperation in interventional, hepatobiliary, oncology, gastroenterology, and pathology departments is required for the entire treatment to determine the most suitable patient plan.
Source: 3D Print Template
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